Difference Between Viruses and Bacteria

Bacteria are unicellular living organisms and are simple in their organizations. They are capable of multiplying by themselves. They are therefore designated as “Prokaryotic” cells in contrast to “Eukaryotic” cells which are more complex. Bacteria exist everywhere, inside and on our bodies. Most bacteria are quite beneficial for us and cause no harm. But, some bacteria cause diseases.

Viruses are a unique group of living agents, extremely small in size, usually beyond the resolution of a light microscope, possess the highest state of parasitism containing a single molecule of either DNA or RNA which has a protein shell and multiply by replication within the living cell. Outside of a living cell, a virus cannot exist. Viruses are not beneficial.

The difference in bacteria and virus is provided below.

Difference Between Viruses and Bacteria




Bacteria
Viruses
Cell
Single Cell
No
Size
Size comparatively larger-in microscope, usually above 300 nm (e. g. - Staphylococcus- 1000nm)

Size very small in the microscope, usually below 300nm, smallpox virus is largest (300nm)

Microscopy
Visible under light microscope

Not visible under light microscope except pox virus

Outer surface
The rigid wall containing peptidoglycan layer

Protein capsid and lipoprotein envelop.

Nucleic acid
Contain both DNA and RNA

Contain either DNA or RNA, never both



Site
Extracellular or intracellular, may grow outside or inside the host cell, active in the extracellular environment
Usually intracellular, must grow inside a living host cell, inert in the extracellular environment, i.e. strict parasites.

Multiplication
Multiply by binary fission

Multiply by replication

Culture
Can grow in inanimate (artificial and cell-free) culture media except for Rickettsiae and Chlamydiae
Cannot grow in inanimate (artificial and cell-free) culture media
Energy-yielding enzymes
Present
Absent
Metabolic activity
Present
Absent


Antibiotic sensitivity
Sensitive or resistant to antibiotics

Mostly resistant to antibiotics

Interferon sensitivity
Resistant to interferon except for Chlamydiae
Sensitive to interferon

Infection
Localized
Systemic
Treatment option
Antibiotics

Vaccines (but not available for all virus)



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